PRL-8-53: The Social Nootropic

prgal

PRL-8-53 (methyl 3-[2-[benzyl(methyl)amino]ethyl]benzoate) is a nootropic drug discovered by Dr. Nikolaus Hansl of Creighton University. Since he patented it in the 1970’s only one clinical trial with humans has been conducted. Based on the study one can conclude it improves recall and verbal memory. Personal accounts on websites like Reddit and Longecity are consistent with one another and corroborate the original findings. Derived from benzoic acid and benzylamine, it chemically and pharmacologically unrelated to the racetams. Although its precise mechanism of action has not been fully elucidated, it is known to act upon several neurotransmitters at once, mostly notably the cholinergic. As Hansl wrote, “retrieval of information that has been accumulated over a period of time, seems mediated by acetylcholine and the cholinergic system.”

PRL-8-53 stories have two fascinating and recurring themes: enhanced recall of events experienced under its influence and a subdued but measurable prosocial effect. In a clinical study on its effects on memory “initial word acquisition performance on PRL-8-53 was only 107.46% of baseline, subjects recalled words at 132.5-142.7% of the baseline rate 24 hours after testing, and at 145.2-146.2% after a week. Stronger effects were noted in the bottom 60% of subjects (who recalled 6 or fewer words on placebo at 24h), with 24 hour retention improved to 187.5-191% of baseline, and one week retention to 200-205%.” It is no doubt a potent potentiator for the creation and retention of memories. Doses range between 2 and 10 milligrams. 5 mg is the most common starting dose. PRL-8-53 is fairly nontoxic; it’s oral LD-50 is 860mg/kg in rats. A man weighing 90kgs (200lbs) would have to consume somewhere in the vicinity of 7740 mg to overdose (assuming the data from rodents does not perfectly translate to humans, and it is doubtful it does, the lesson to be taken is an unreasonable amount of the compound must be ingested before it is even slightly toxic). This is not an exhortation to take more than the recommended amount.

PRL is a cholinergic, a dopamine potentiator and serotonin inhibitor. Unlike MDMA, PRL is not an empathogen. It is not a stimulant either. Nor does it seem to be, like aniracetam, a general anxiolytic since some users list feelings of uneasiness after dosing (even though, somewhat paradoxically, in these same case studies participants have also noticed improved ease in communicating with others). Similar to some racetams, a slight dulling of emotional intensity has been reported. Subjects who have administered the drug to themselves notice “social barriers” evaporating. They do not feel talkative or compulsively gregarious or irrepressibly manic; they feel more at ease in interacting with other people. Severe social anxiety afflicts nearly 7% of American adults. How many more suffer from less crippling forms of the disorder is not known. At this time very little research has been done on pharmaceuticals that specifically target social anxiety (not tranquilizers or general anxiety medications). For this reason PRL and its as of yet undiscovered cousins should be of great interest to researchers looking for the next typhoon in the always engaging field of neuropsychopharmacology.

The richest and most exciting source of information about PRL is Reddit. One fellow “wrote a program based on an NP-Complete math problem that works, and successfully presented another piece of software to a couple of Venture Capitalists without the slightest bit of nervousness or hesitation.” Another “programmed a java assignment the entire day. 8 hours and then 5 hours into the morning.” He was less prone to indulging in distractions. Like many other psychotropics PRL is, anecdotally, a potentiator of vivid dreams. Whether or not it can foster lucid dreaming is not known.” It promotes concentration without stimulation. It is consistently described as a “clean” feeling, an energetic state free from euphoria or rage. One Redditor observed that the hyperfocus it promotes can be cumbersome to someone who wishes to let their mind wander. For someone who needs to complete a particular task within a particular amount of time this should not be an issue. He, one of the least effusive of the reviewers, writes, “this drug does NOT make you happier. It does NOT make you upset. It doesn’t really affect your everyday perception. All it seems to do is make memorization a bit easier, give you a little bit extra energy, and allow reading to be a lot easier because you retain the information that much faster.” It shines brightest in crowded room: “social benefits appear to be an increased recall of events, situations, and details. I’m still fishing around for the right words like I usually do, however. This in turn seems to subjectively boost sociability. I still had mild anxiety issues in certain situations. However, I was able to address a crowd of people on a moment’s notice and it felt completely natural.”

Before concluding it is worth mentioning PRL-8-53’s legendary cousin,  PRL-8-147, which is purported to grant godlike powers to whoever finds the golden chalice in which the only known sample resides dissolved in the finest mead of Middle Earth. Joking aside, Dr. Hansl left his research papers to his family. Right now little is verifiable about 147 and at this time there are no reputable suppliers. Do not despair, PRL-8-53 is quite promising.

Branconnier, Roland J. “The human behavioral pharmacology of the common core heptapeptides.” Pharmacology & therapeutics 14.2 (1981): 161-175.

 

Brewster, Marcus E., et al. “Brain-enhanced delivery of anti-dementia drugs.”Novel Approaches to the Treatment of Alzheimer’s Disease. Springer US, 1989. 173-183.

 

Esler, William K. “Physiological studies of the brain: implications for science teaching.” Journal of Research in Science Teaching 19.9 (1982): 795-803.

 

Hansl, Nikolaus R., and Beverley T. Mead. “PRL-8-53: Enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent.” Psychopharmacology 56.3 (1978): 249-253.

 

Hull, Ronald W. “Metaperspectives for the Future: Technology.” (1980).

 

1 Kessler RC, Chiu WT, Demler O, Walters EE. Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Archives of General Psychiatry, 2005 Jun;62(6):617-27.

 

Valenta, Vladimír, et al. “Potential nootropic agents: Synthesis of a series of (2-oxo-1-pyrrolidinyl) acetic acid piperazides.” Collection of Czechoslovak Chemical Communications 55.6 (1990): 1613-1629.

 

Various. “PRL-8-53 Experiences • /r/Nootropics.” Reddit. N.p., Nov.-Dec. 2013. Web. 16 Sept. 2014.

Advertisements

2 comments

  1. You’re mistaken…PRL 8-147,was never claimed, as a compound that would give one “GOD Like Powers.” Where did you hear this? Who ever said it, is wrong and clearly doesn’t know what their talking about! Dr. Hansl, was an honorable person…in fact he was unset, to learn that an article published by Phi Deta Kappa, a journal published for professional educators, used the phrase “Smart Pill.” in the titled article. on PRL 8 – 53. PRL 8-147, certainly, won’t give anything one intellectual capabilities they don’t naturally possess! I would appreciated that your remarks regarding PRL 8-147, claimed by some, that it could offer, the potential to acquire super mental or god like capabilities be removed…it’s a disservice to his reputation, the people who worked with him, his former wife (co-researcher) and his published scientific work, which is considerable and goes far beyond what appears on the web. Sincerely, GPH

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s